If adequate controls of the sterilising process and storage are carried out, sterilisation by ethylene oxide is considered to be safe for new plastics and clean equipment. July 1, 2014 product uses1,4 ethylene is primarily used as a reactive monomer chemical building block make polyethylene and as an intermediate in the production of other organic compounds, such as ethylene dichloride and ethylene oxide. Ethylene oxide eo is a very versatile compound with considerable energy in its ring structure. Ethylene oxide eto fact sheet hazard evaluation system and information service hesis occupational health branch 850 marina bay parkway building p, 3rd floor richmond, ca 94804 866 2825516.
Testing may be performed on workers who perform jobs that may cause exposure to possible lung hazards, are physically demanding, or. The incorporation of both canadian newco and meglobal b. It is intended to provide general information to persons who may handle or store ethylene oxide. Ethylene oxide 75218 hazard summary the major use for ethylene oxide is as a chemical intermediate in industry. Propylene oxide po is an extremely versatile chemical intermediate used to produce a. Safety data sheet envirosystems ethylene oxide sterilant.
Ethylene oxide, mustard gas and other organics, and to accelerate the ripening of fruits. Ethylene oxide msds pdf ethylene flammability scribd. Volatilization of propylene oxide from the aquatic environment may be an important transport mechanism. Ethylene oxide, called oxirane by iupac, is an organic compound with the formula c 2 h 4 o. This product can expose you to chemicals including ethylene oxide and naphthalene which are known to the state of california to cause cancer and birth defects or other reproductive harm. Acute inhalation exposure of workers to high levels of ethylene oxide has resulted in nausea, vomiting, neurological disorders, bronchitis, pulmonary edema, and emphysema. It is produced by direct oxidation of ethylene with air or oxygen. Ethylene oxide is generally synthesized by chlorohydrine process and direct oxidation of ethylene with air, catalyzed by silverag. Eto is used in the manufacture of ethylene glycol, surfactants, ethanolamines, glycol ethers, and other organic. Sigmaaldrich material safety data sheet date printed. Ethylene oxide sterilization is an important sterilization method that manufacturers widely use to keep medical devices safe.
All atsdr toxicological profile pdf files are electronic conversions from paper copy or other electronic ascii text files. As attorneys general, we are charged in each of our respective states with enforcing laws to protect the health and safety of our residents. Ethylene dichloride ethylene dichloride ethylene dichloride hazard class. Occupational exposure limits for chemical substances, occupational health and safety regulation 29697, as amended 07 2007 stel 1 ppm canada. Safety data sheet ethylene oxide linde hiq linde gas. Take the victim to a doctor or medical facility at once. Ineos oxide homepage europes largest producer of ethylene. Ineos oxide is europes largest producer of ethylene oxide, europes largest producer of ethylene glycol, the worlds number one seller of ethanolamines, the worlds second largest producer of ethylidene norbornene enb. Safety data sheet air liquide msds document library. All electrical devices used in areas processing or handling ethylene oxide must be engineered and designed to the applicable local electricalfire codes. Description of first aid measures firstaid measures general. Shortterm exposures can also affect the central nervous system, leading to symptoms such as drowsiness, disorientation, nausea, and vomiting.
Contents of this msds comply with the osha hazard communication standard 29 cfr 1910. Ethylene oxide cas no 75218 ec no 2008499 ec index no 60302300x registrationno. May 1, 2014 the dow chemical company page 4 of 7 secondary infections, which can lead to pneumonia. Ethylene oxide is a manmade chemical that is used primarily to make ethylene glycol a chemical used to make antifreeze and polyester. We are concerned that the current epa standard for eto fails to adequately protect workers and. Identification of the substancemixture and of the companyundertaking 1. Oshaniosh spirometry infosheet a spirometry breathing test shows how well you can move air in and out of your lungs. This msds complies with the canadian controlled product. Ethylene oxide sds ref sds056clp air liquide uk ltd. Its reactions proceed mainly via ring opening and are highly exothermic.
Ethylene oxide please note that the layout and pagination of this pdf file are not identical to those of the printed cicad first draft prepared by r. Focuses on some of the hazards and controls found in the hospital setting and describes standard requirements as well as recommended safe work practices for employee safety and health. Comments on texas commission on environmental quality. Ethylene oxide is a flammable gas with a somewhat sweet odor. Station road, coleshill b46 1jy birmingham united kingdom 01675462424. The block copolymer electrolyte used in figure 4 of the main text ps molecular weight of 1. Msds format on a 16 section based on guidance provided in. Safeguards can include designing electrical devices as explosion proof andor intrinsically safe. Center for devices and radiological health ethylene oxide. The principal application of ethylene oxide is the manufacture of ethene glycol or ethylene glycol and higher alcohols used in automotive antifreeze, explosives, cellophane, synthetic rubbers and lubricants as well as solvents and hydraulic fluids. The acute shortterm effects of ethylene oxide in humans consist mainly of central nervous system cns depression and irritation of the eyes and mucous membranes. The ethylene oxide product stewardship guidance manual was prepared by the american chemistry councils ethylene oxideethylene glycols panel panel.
When used to sterilize health care items, this product must be used in nonportable. Ril msds ethylene oxide reliance industries limited. Safety data sheet, per the requirements of the osha hazard communication. The following references aid in recognizing and evaluating ethylene oxide hazards in the workplace. This chemical is on the special health hazard substance list because it is flammable and reactive. You may need a pdf reader to view some of the files on this page. Carr, epd file complaint against bd for violations of. This product may be used only by persons who have been trained in accordance with the ethylene oxide standard 29 cfr 1910. See epas about pdf page to learn more ethylene oxide aegl technical support document pdf 114 pp, 705 k. Because it is a strained ring, ethylene oxide easily participates in a number of addition reactions that. Ethylene oxide is considered by osha, ntp and iarc as a potential human carcinogen and mutagen. Epa has concluded that ethylene oxide is carcinogenic to humans by the. Ethylene oxide is a colorless gas or liquid with an etherlike odor.
Exposure to ethylene oxide may cause headache, nausea, vomiting, diarrhea, breathing difficulty, drowsiness, weakness, exhaustion, eye and skin burns, frostbite, and reproductive effects. Full text get a printable copy pdf file of the complete article 796k, or click on a page image below to browse page by page. Ethylene oxide in presence of water can hydrolyze to ethylene glycol and form poly ethylene oxide which then eventually gets oxidized by air and leads to hotspots that can trigger explosive decomposition. Because it reacts readily with other chemicals, hpeo is one of the most versatile intermediates and is used to produce many derivative products. Osha publications ethylene oxide occupational safety. It is very water soluble and solutions of as little as 4% in water are flammable. Ethylene oxide is a colorless and flammable gas with a faintly sweet odor. Meglobal ethylene, ethylene glycol, ethylene oxide, polyethylene, styrene monomer. Safety data sheet mono ethylene glycol 1 identification of the substancepreparation and companyundertaking application automotive industry.
Ethylene oxide is on the right to know hazardous substance list because it is cited by osha, acgih, dot, niosh, ntp, dep, iarc, nfpa and epa. European community eec label symbol and classification xi irritant r38r43 irritating. Beckman coulter kit msds university of california, davis. Ethylene oxide results aegl program acute exposure. Provides information on hazards and methods of exposure prevention regarding ethylene oxide gas. Ethylene comprises the mapa prahy pdf bulk of albertas petrochemical production, with. Increased incidences of chromosomal aberrations and sister chromatid exchanges have been observed in workers exposed to ethylene oxide. Material source hazard designation ethylene dichloride acgih not classifiable as a human carcinogen. Iarc has classified ethylene oxide as a group i carcinogen carcinogenic to humans. It is also used in the manufacture of flexible and rigid polyurethane foams, brake fluids, and. Peters a, nandita akunuri a, joshua hleb ak a, vijay gupta a, qinghe zheng a, s. Ethylene dichloride edc material safety data sheet page 6 of 11 skin notation means that significant exposure can also occur by absorption of liquid through the skin and of vapour through the eyes or mucous membranes.
As a part of the chemical industrys responsible management of its products, the ethylene oxide panel ethylene oxide safety task group stg, a group comprised of producers and industrial users, developed the ethylene oxide product stewardship manual 3rd edition. Ethylene oxide c2h4o safety data sheet sds p4798 praxair, inc. It is also used in the manufacture of flexible and rigid polyurethane foams, brake. It is not intended to serve as a substitute for indepth training or. From september 15, 2019 through september 22, 2019, bd violated the georgia air quality act and the rules for air quality control when it negligently allowed the release of 54. Under some conditions, it is known to undergo a variety of reactions, such as isomerization, polymerization, hydrolysis, combustion and decomposition. All whmis required information is included in appropriate sections based on the ansi z400. Occupational exposure limits, if available, are listed in section 8.
Mannan ethylene oxide eo is a very versatile compound with considerable energy in its ring structure. Not applicable ingredients on ingredient disclosure. It is also an important intermediate in the the manufacture of certain detergents. Occupational exposure limits for chemical substances, occupational health and safety regulation. The ethylene oxide product stewardship guidance manual was prepared by the american chemistry councils ethylene oxide ethylene glycols panel panel. This product contains a chemical known to the state of california to cause cancer and reproductive harm. Us epa, pesticide product label, ethylene oxide, 052020. Ethylene oxide hazardous polymerization will not occur section vi health hazard data routes of entry. Mixing of equal weights of ethylene glycol and potassium dichromate at 100c. Ethylene oxide cas no main constituent 75218 100 3. This product contains the following toxic chemicals subject to the reporting requirements of section 3 of the emergency planning and community.
High purity ethylene oxide hpeo is a colourless, highly reactive and flammable gas at room temperature. Application ethylene oxide can be used as a precursor to synthesize. Osha, cma, ansi and canadian whmis standards part i what is the material and what do i need to know in an emergency. Epa has concluded that ethylene oxide is carcinogenic to humans by the inhalation route of exposure. Through the use of a vacuumbased process, eo sterilization can efficiently penetrate surfaces of most medical devices and its lower temperature makes it an ideal process. Ethylene oxide sds ref al069 air liquide australia limited level 9 380 st. Reactivity of ethylene oxide in contact with contaminants. If patient is unconscious, or in case of danger of blackout, transport patient in a stabilised.
National institute for occupational safety and health niosh current intelligence bulletin 35, may 22. Reason for citation ethylene is on the hazardous substance list because it is cited by acgih, dot, dep, nfpa and epa. Fires caused by ethylene oxide are extinguished by traditional media, including foam, carbon dioxide or water. A mixture of phosphorus v sulfide, ethylene glycol, and hexane in a mantleheated flask spontaneously overheated and exploded at an internal temperature of about 180c. Lewis, environment canada, ottawa, canada published under the joint sponsorship of the united nations environment programme, the. Substance safety data sheet for ethylene oxide nonmandatory.
Material safety data sheet ethylene dichloride msds name. Revised march 1991 table of contents find out if you are working with ethylene oxide how ethylene oxide enters and affects your body. Ethylene oxide eto cas 75218 physical hazards ethylene oxide eto is an extremely flammable and reactive material which is a gas at room temperature. This chemical is on the special health hazard substance list. Department of health and human services, public health service. Canada this product is exempt from whmis label and msds requirements. Ethylene oxide sterilization for medical devices fda. Important in all cases of exposure, get or summon medical treatment immediately. A small amount less than 1% is used to control insects in some stored agricultural products and a very small amount is used in hospitals to sterilize medical. Ensure activity of vitally important functions until the arrival of the doctor artificial respiration, inhalation of oxygen, heart massage. The main sources of information for this fact sheet are. Apf 50 any airpurifying, fullfacepiece respirator gas mask with a chinstyle, front or backmounted canister providing protection against ethylene oxide. There also is some evidence linking ethylene oxide exposure to reproductive effects. Safety and health topics ethylene oxide occupational.
Ethylene oxide also known as eo or eto is a low temperature gaseous process widely used to sterilize a variety of healthcare products, such as singleuse medical devices. Substance any concentration shown as a range is to protect confidentiality or is due to batch variation. If released to the atmosphere, propylene oxide will react in the vapor phase with photochemically produced hydroxyl radicals with an estimated halflife of approximately 30 days. The adultbased inhalation cancer risk estimate for ethylene oxide, called the unit risk estimate, was changed from 0. Sep 26, 2019 toxicological profile for ethylene oxide. Material safety data sheet richardallan scientific 4481 campus drive kalamazoo mi 49008 chemtrec 800 4249300 8005227270 8.
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